Children with oral clefts show a wide range of dental anomalies, adding complexity to understanding the phenotypic spectrum of orofacial clefting. The evidence is mixed however on whether the prevalence of dental anomalies is elevated in unaffected relatives, and is mostly based on small samples. This study by researchers Brian J. Howe, Margaret E. Cooper, Alexandre R. Vieira, Seth M. Weinberg, Judith Resick, Nichole Nidey, George L. Wehby, Mary L. Marazita and Lina Moreno Uribe characterizes the spectrum of cleft-related dental anomalies and evaluates whether families with clefting have a significantly higher risk for such anomalies compared to the general population. A total of 3,811 individuals were included with the breakdown being 660 cases with clefts, 1,922 unaffected relatives and 1,229 controls.