Before Getting Dental Implants: Gene Combination Identified As Risk Factor In Success Of Dental Implants. The health of your surrounding tissue and gums affects the success of a dental implant. Therefore identifying and reducing the risk factors is a critical step in the implant process. Now a combination of genes has been identified as a possible indicator of more significant tissue destruction leading to adverse outcomes for implants. An article in the Journal of Oral Implantology reports a study of individuals with the combination of interleukin (IL)-1 allele 2 at IL-1A-889 and IL-1B+3954. These people are “genotype positive” and are susceptible to increased periodontal tissue destruction.